Distribution of mutations in the total cohort based on TP53^MT status. (A) The mutation landscape and network with complex karyotype of the total cohort (n = 349). (B) The mutation landscape in a chord diagram for all patients with TP53^MT (n = 49). (C) Frequencies of cooccurring driver and other mutations in patients with TP53^MT and TP53^WT. (D) Frequencies of cooccurring driver and other mutations in patients with TP53^MT with single- vs multihit constellations.