Time until definitive improvement Kaplan-Meier curves for exploratory EORTC QLQ-C30 global health status/QoL, EORTC QLQ-C30 physical functioning, EQ-5D-5L VAS, and EORTC QLQ-C30 dyspnea. Cumulative incidence of improvement (greater than the minimally important difference) in scores from baseline with no further decline, controlling for death as a competing risk; an event was defined as the first time reaching the threshold for improvement and no deterioration below the threshold at later time points. Patients who had PRO assessments after an EFS event (supplemental Results) were not censored to avoid biasing results by excluding patients with worse outcomes. + on the curve, censor; CIF, cumulative incidence function; NE, not estimable.