Figure 5.
Recurrent genetic lesions in mature NK-cell and T-cell neoplasms with potential therapeutic intervention. Representative histology of entities with frequent genetic lesions potentially amenable to therapeutic intervention are shown on the left. The genetic lesions are presented according to functional groups related to TcR signaling, JAK/STAT pathway, epigenetics, or others. Therapeutic efficacy is supported by clinical trial (a); case reports, small case series, or retrospective analyses (b); or experimental or in silico data (c). AITL, Angioimmunoblastic T-cell lymphoma; ATLL, adult T-leukemia/lymphoma; CTCL, cutaneous T-cell lymphoma; ITLPD-GI, indolent clonal T-cell LPD of the gastrointestinal tract; TFHL-F, TFHL, follicular type; T-PLL, T-cell prolymphocytic leukemia. Sources referenced: 268, 270, 278, 284, 291, 293, 330, 338, 339, 341, 345, 475-487.

Recurrent genetic lesions in mature NK-cell and T-cell neoplasms with potential therapeutic intervention. Representative histology of entities with frequent genetic lesions potentially amenable to therapeutic intervention are shown on the left. The genetic lesions are presented according to functional groups related to TcR signaling, JAK/STAT pathway, epigenetics, or others. Therapeutic efficacy is supported by clinical trial (a); case reports, small case series, or retrospective analyses (b); or experimental or in silico data (c). AITL, Angioimmunoblastic T-cell lymphoma; ATLL, adult T-leukemia/lymphoma; CTCL, cutaneous T-cell lymphoma; ITLPD-GI, indolent clonal T-cell LPD of the gastrointestinal tract; TFHL-F, TFHL, follicular type; T-PLL, T-cell prolymphocytic leukemia. Sources referenced: 268, 270, 278, 284, 291, 293, 330, 338, 339, 341, 345, 475-487.

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