Multiple mechanisms drive VEN resistance even within a patient. (A) Schematic of RaCH-seq workflow. (B) CLL cells from CLL6 at relapse with altered gene expression (left), cluster assignments (middle), and BAX^γ isoform (right). (C) Violin plots showing expression of NF-κB genes (left), MCL1 (middle), and BCL2 (right) for CLL6 screening or at relapse, with or without BAX^γ. (D) CLL cells from CLL2 at relapse showing expression for the indicated genes (left, in red), with cluster assignments (middle), and RaCH-seq data for variants of interest (right, in black). (E) H3K27ac ChIP at the BCLxL locus in flow-sorted (left) CD19^+veCD5^+ve BCLxL^hi (blue) or BCLxL^lo (red) cells from CLL2; data representative of 2 independent experiments.