Time to first treatment in the training cohort. (A) Log-relative hazard according to the CLL15 score. (B) Kaplan-Meier curves of the TtFT of the 3 patient groups identified by the CLL15 assay. (C) Kaplan-Meier curves of the TtFT of the 3 patient groups identified by the CLL15 assay in the subgroup of patients with early-stage disease (Binet A 0/I). (D) Kaplan-Meier curves of the TtFT according to CLL15 assay and IGHV mutational status.