Kinetics of cytokine production and association with CRS. (A) Expresses the production of individual cytokines (vertical axis) over time (horizontal axis) from individual patients (unique patient number not shown). Changes in cytokine levels are shown as fold-change from the day −1 baseline on a log₂ scale. (B) Shows the correlation of peak cytokine production of selected cytokines out of 30 cytokines tested with CRS severity (using the Penn scale of CRS severity). Pearson correlation with a Bonferroni correction for multiple comparisons. Note that the remaining 26 cytokines tested were not found to be significantly correlated with CRS severity.