Plasma chemokine, cytokine, and growth factor levels are influenced by disease burden, lymphodepleting chemotherapy, and CRS/ICANS. (A) Day −5 (before lymphodepleting chemotherapy), t test, ∗P < .05 and ∗∗P < .01. (B and C) Change in plasma chemokine, cytokine, and growth factor levels before and after lymphodepleting chemotherapy. (B) Individual chemokine, cytokine, and growth factor levels, t test, ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001. (C) Sum of all chemokine, cytokine, and growth factor levels (CytoSum), t test, ∗P < .05. (D) Principal component analysis. (E) Loess plots comparing plasma chemokine, cytokine, and growth factor levels in patients with or without CRS and/or carHLH.