Variant Allele Frequency Trajectories. (A-D) Show variant allele frequency trajectories (for samples taken at diagnosis with FL and with DLBCL) for a selection of individual patients (numbers 6, 7, 25, and 26, respectively, in [A-D]). Gene/sites are annotated. Patient 6 shows a complex set of gains with selection for HLA-B mutations; patient 7 shows a complex set of gains; patient 25 shows substantial shared mutation burdens, with a couple of gains from zero and one loss and Includes EZH2 as a shared mutation; patient 26 shows a core set of 5 mutations and major gain in CREBBP.