OS of all patients with follow-up data, by cluster. (A) OS of patients by BIC cluster. (B) OS of patients by AIC cluster. (C) OS of patients initially put on “Watch-and-Wait” therapy by BIC cluster. (D) OS of patients initially put on “Watch-and-Wait” therapy by AIC cluster. (E) OS of patients initially treated with chemotherapy by BIC cluster. (F) OS of patients initially treated with chemotherapy by AIC cluster.