Proportions of clinically meaningful changes from baseline in the primary domains of interest. (A-F) Proportion of clinically meaningful changes in EORTC QLQ-C30 GH/QOL (A), physical functioning (B), cognitive functioning (C), fatigue (D), pain (E), and FACT-LymS (F). Clinically meaningful change (improvement or deterioration) from baseline in EORTC QLQ-C30 score was determined using a RD based on minimal change thresholds (ie, smallest incremental change) as recommended by Cocks and Buchanan²² as follows: 5 points for GH/QOL, physical, and emotional functioning; 10 points for fatigue; 15 points for role, cognitive, social functioning, nausea/vomiting, and pain; and 30 points for all other domains. For the FACT-LymS, a cutoff value of 3 was defined as the within-group and between-group MID and RD.²⁴ Numbers of evaluable patients at each visit were based on data available for the variable at the given visit. ∗P < .05. Asterisks above bars indicate significant differences in proportions of patients exhibiting clinically meaningful improvement vs no clinically meaningful improvement. Asterisks below bars indicate significant differences in proportions of patients exhibiting clinically meaningful deterioration vs no clinically meaningful deterioration. GH/QOL, global health status/QOL.