Observed mean changes from baseline in the primary domains of interest. (A-F) Observed mean changes from baseline in EORTC QLQ-C30 global health status/QOL (A), physical functioning (B), cognitive functioning (C), fatigue (D), pain (E), and FACT-LymS (F). Numbers of evaluable patients at each visit were based on data available for the variable at the given visit. ∗P < .05.