Schematic representation of hematopoiesis. In this reconciled model of HSC differentiation, HSCs and their downstream progenies, multipotent progenitor (MPP), common myeloid progenitor (CMP), and common lymphoid progenitor (CLP) cells are part of a continuum and do not represent discrete cell types. They gradually acquire lineage-specific transcriptomic states and differentiate into lineage-restricted cells. GMP, granulocyte-macrophage progenitor; MEP, megakaryocyte-erythroid progenitor; MkP, megakaryocyte progenitor.