Exploratory analyses of ctDNA and PET with clinical outcomes. Waterfall plot with x-axis plotted from treatment initiation representing log change in ctDNA levels at cycle 3 day 1 (A) and EOT (B). Green bars represent patients with no evidence of relapse and the red bar represents the only patient with evidence of recurrence. Below each bar is a square that indicates the PET result at the same time point. Blue squares represent a complete metabolic response (Deauville 1-3) and orange squares indicate FDG uptake (Deauville 4, 5, or X). Of note, 2 patients with detectable ctDNA at baseline that only received 2 total cycles of treatment on study were represented on both waterfall plots. One patient who came off study after cycle 3 day 1 because of toxicity and received alternate frontline treatment was represented only on the cycle 3 day 1 waterfall plot. Survival analyses comparing PFS in patients with detectable or undetectable ctDNA at cycle 3 day 1 (C) and the EOT (D). ND, not detected.