Figure 2.
HbS is responsible for the activation of the NF-κB and type I interferon signaling pathways. mRNA expression profile of human monocytes from healthy blood donors (n = 4) after 4-hour incubation with HbS (20 μM), HbA (20 μM), or control (NanoString Inflammation Panel, Canopy Biosciences). Presented genes (n = 57 out of 255) are those with a statistically significant >1.5-increase in mRNA expression after incubation with HbS compared with HbA. Heat map representation of the 57 genes is ordered by hierarchical clustering, using a logarithmic scale color bar. IL-6, CCL3, CCL4, IL-1α, IL-1β, TNF-α, CXCL2, CXCL3, and IL-10 belong to the NF-κB signaling pathway, whereas IFIT2, IFIT3, OAS2, CSF3, IFI44, IFNB1, and OASL belong to the type I signaling pathway.

HbS is responsible for the activation of the NF-κB and type I interferon signaling pathways. mRNA expression profile of human monocytes from healthy blood donors (n = 4) after 4-hour incubation with HbS (20 μM), HbA (20 μM), or control (NanoString Inflammation Panel, Canopy Biosciences). Presented genes (n = 57 out of 255) are those with a statistically significant >1.5-increase in mRNA expression after incubation with HbS compared with HbA. Heat map representation of the 57 genes is ordered by hierarchical clustering, using a logarithmic scale color bar. IL-6, CCL3, CCL4, IL-1α, IL-1β, TNF-α, CXCL2, CXCL3, and IL-10 belong to the NF-κB signaling pathway, whereas IFIT2, IFIT3, OAS2, CSF3, IFI44, IFNB1, and OASL belong to the type I signaling pathway.

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