CHIP with VAF ≥ 0.1 is not associated with increased 28-day in-hospital mortality in primary cohort. (A) Generation of the primary MGH cohort. (B) Distribution of genes mutated in patients found to have CHIP with a VAF of 0.1 or greater in the MGB cohort. (C) Forest plot of multivariable analysis within MGB cohort (adj P value, adjusted P value). (D) Cumulative 28-day mortality among patients with and without CHIP (VAF ≥ 0.1) in the MGB cohort.