Clinical outcomes in patients treated with R-CHOP according to SVs in MYC, BCL2 and/or BCL6 detected by FISH. (A-B) FFP and OS according to FISH-defined double-hit lymphoma subgroups: HGBCL-DH-BCL2 and HGBCL-DH-BCL6, with the remaining majority of patients defined as non-HGBCL-DH. (C-D) FFP and OS after separating patients with atypical-DH lymphoma as defined in supplemental Figure 11A from the non-HGBCL-DH group into a distinct subgroup with the remaining majority of patients defined as non-double-hit (non-DH). ∗∗∗∗P < .0001, ∗∗∗P < .001, ∗∗P < .01, ∗P < .05.