Proportion by age group and clinical outcomes of DLBCL patients in the study population according to GEP–defined molecular subgroups using the DLBCL90 assay. (A) COO subgroup distribution according to age group at diagnosis. (B) DZsig distribution according to age group at diagnosis. P values of categorical comparisons across age groups were derived from χ² test. (C-D) FFP and OS according to COO classification in patients treated with curative-intent R-CHOP. (E-F) FFP and OS in patients treated with R-CHOP after removing patients with DZsig positive (DZsig^pos) DLBCL from the GCB and unclassified COO (UNCLASS) subgroups, to form the DZsig^pos subgroup. Log-rank test was used to compare survival curves. ∗∗∗∗P < .0001, ∗∗∗P < .001, ∗∗P < .01, ∗P < .05.