Figure 2.
Characterization of C1INH-deficient mice. (A) Western blot of C1INH and transferrin with corresponding (B) densitometric analysis in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. (C) Ratio of cleaved to total high molecular weight kininogen in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. Data are represented as mean ± standard deviation and analyzed by one-way ANOVA with post hoc Bonferroni. Levels of (D) F1+2 and (E) TAT complexes in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. (F) aPTT and (G) prothrombin time assays in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. Data are represented as individual values with median and interquartile range and analyzed by Kruskal-Wallis with post hoc Dunn’s. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001 ∗∗∗∗P < .0001. ANOVA, analysis of variance.

Characterization of C1INH-deficient mice. (A) Western blot of C1INH and transferrin with corresponding (B) densitometric analysis in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. (C) Ratio of cleaved to total high molecular weight kininogen in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. Data are represented as mean ± standard deviation and analyzed by one-way ANOVA with post hoc Bonferroni. Levels of (D) F1+2 and (E) TAT complexes in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. (F) aPTT and (G) prothrombin time assays in plasma from C1inh+/+, C1inh+/−, and C1inh−/− mice. Data are represented as individual values with median and interquartile range and analyzed by Kruskal-Wallis with post hoc Dunn’s. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001 ∗∗∗∗P < .0001. ANOVA, analysis of variance.

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