Association of etoposide genes from CRISPR screen with outcome in pediatric AML. (A) High expression of EtoRGs: PRKDC and RAD54L2 showed unfavorable EFS, OS, and RR in pediatric AML. (B) High expression of EtoSGs: TKT with favorable EFS, OS, and RR; RPE with better EFS and OS; CSK1B with favorable OS; and SKP2 with lower RR in pediatric patients with AML treated in AML02 trial. Corresponding STRING networks showed interactions with respective genes with other genes. (∗, ∗∗, ∗∗∗ indicate significant terms at the P < .05, P < .01, and P < .001 statistical levels, respectively). Gene expression association analysis was performed with (referred as Risk adj) or without adjusting (referred as Unadj) for the initial risk group assignment.