Degree of sharing of predicted mHAs across the study population. (A) Shows the distribution of predicted mHAs by the number of patients in the DISCOVeRY-BMT cohorts that possess them. Most mHAs are shared by ≤10 patients. Inlaid are the same data with y transformed y-axis to highlight the tail of the distribution. Data are colored by quartile of number of patients for each mHA. (B) Shows the distribution of predicted HLA-A∗02:01 mHAs by population frequency in DRPs with HLA-A∗02:01. (C) Shows the distribution of predicted HLA-B∗35:01 mHAs by population frequency in DRPs with HLA-B∗35:01. (D) Shows the distribution of predicted HLA-C∗07:02 mHAs by population frequency in DRPs with HLA-C∗07:02. (E) Shows the percentage of DISCOVeRY-BMT cohort with each HLA allele covered by each predicted GVL mHA that binds that HLA allele, for all HLA alleles representing >0.5% of DISCOVeRY-BMT patients.