Cumulative incidence of aGVHD and cGVHD. The cumulative incidence of (A) grades 2 to 4 aGVHD was 22% (17% to 26%) at both 6 and 12 months post-HSCT (blue line), with 8% (5% to 11%) developing grades 3 to 4 aGVHD at both 6 and 12 months post-HSCT (red line). The cumulative incidence of (B) all cGVHD (limited and extensive) was 16% (12% to 20%) at 1 year and 19% (15% to 24%) at 5 years (blue line), whereas extensive chronic GVHD was seen in 7% (4% to 9%) at 1 year and 7% (4% to 10%) at 5 years (red line).