Genomic and transcriptomic analyses. (A) Oncoprint plot with driver mutations landscape in PTCL cohort. Each sample is shown on the x-axis, with 4 major driver mutations on the y-axis. Different colors depict different types of mutations. (B) Lollipop plots representing distribution of 4 major driver genes. All amino acid positions are depicted on the x-axis, with colored blocks representing protein domains. (C) Clonal evolution analysis of longitudinal biopsy samples from patient with relapsed disease. x-axis denotes putative time points of mutation emergence, and real time points of the biopsies. Main clone is colored with green, 2 subclones with red and yellow. (D) Volcano plot of differential gene expression in paired tumor specimens before (C1D-6) and after Aza priming (C1D1) by RNA sequencing analysis. (E) Waterfall plot with differentially expressed gene set terms. Each bar represents a gene set, red stands for upregulated gene set, and blue stands for downregulated gene set. Upregulated and downregulated genes were subjected to gene set enrichment analysis. Top DEG with bonferroni-adjusted P value < .05 and absolute log2FC higher than 1.