CMV prevention strategies in HCT, including potential combined approaches. Red circles indicate weekly monitoring for CMV viremia; open circles indicate test time points that yielded viral loads below the threshold for the initiation of PET antiviral therapy; filled shapes indicate test time points with values above this threshold. Black arrows indicate the administration of antiviral PET. Black bars indicate administration of antivirals as prophylaxis. Blue triangles indicate administration of vaccine dose. All the strategies include clinical surveillance. ^aVaccination of transplant donor and/or recipient; ^bvarious vaccination schedules used; ^cvarious experimental vaccines currently being studied. D⁺R⁻, donor positive, recipient negative; Exp, experimental; IM, immune monitoring; PET, preemptive therapy; R⁺, recipient positive; RCT, randomizwd controlled trial; Tx, therapy. Reproduced with permission from Limaye et al.³