Mouse RBC storage upon supplementation of S1P decreases post-transfusion recovery. Post transfusion recovery studies were performed in FVB and C57BL/6 mice upon storage of RBCs for 3 and 6 days in presence or absence of exogenously supplemented S1P (5 μM) (A). Decreases in PTR (median ± ranges) were observed in S1P supplemented mice for 3 and 6 days (B-C). S1P had a measurable effect on stored RBC glycolysis, free and acyl-conjugated carnitines in both good storer C57BL/6 and poor storer FVB mice over storage duration (heat maps in panels D and E, respectively, showing triplicate metabolite measurements at storage days 3 and 6).