Inflammatory response in Eμ-myc lymphoma cells residing in Tpo^Tg mice. (A) Pathway analysis of hallmark gene sets in blood-residing Eμ-myc lymphoma cells of Tpo^Tg mice was compared with WT mice. Significantly upregulated pathways associated with inflammation are indicated with asterisks. (B) Differentially expressed genes are presented in a mean difference plot when comparing blood-residing Eμ-myc cells of Tpo^Tg mice with WT mice. Significantly upregulated genes are indicated in red and downregulated genes in blue. Significantly upregulated genes associated with an inflammatory response are circled in green. They include hallmark gene sets: inflammatory response, IL-2 STAT 5 signaling, and TNF-α signaling via NF-κB. FDR, false discovery rate.