Increased sP-selectin levels in mice with lymphoma. (A) WBC count, (B) spleen weight, (C) platelet count, and (D) serum sP-selectin concentration in WT C57BL/6 mice 3 weeks after Eμ-myc 5849 IV transplantation (2 × 10⁴ immortalized cells per mouse). Student unpaired t test. n = 4 untreated control mice; n = 8 to 14 mice transplanted with Eμ-myc. Each symbol represents an individual mouse. Mean ± SEM, ∗P < .05, ∗∗P < .005. (E) WBC count and (F) spleen/body weight ratio correlated with sP-selectin concentration in serum. Clear circles = control mice (n = 4). Black circles = mice transplanted with Eμ-myc (n = 8). Linear regression analysis. sP-selectin, soluble P-selectin.