Immunomodulatory functions of Tregs to control GVHD. In a mouse GVHD model, CD4⁺ and CD8⁺ Tcons profiled in secondary lymphoid organs were transcriptionally and metabolically altered upon Treg administration but showed preserved activation, TCR clonal restriction, and cytotoxic gene programs.¹ Treg-derived IL-10 and IL-35 emerged as candidate pathways to mediate these effects. The presence of Tregs also blunted T-cell accumulation in the gut, which is a key GVHD target organ. OXPHOS, oxidative phosphorylation.