![The presence of multiple t(4;14) myelomas is illustrated in this schematic figure. Tumor cells from patients with t(4;14) may look similar under the microscope during morphologic and cytogenetic assessments (using fluorescence in situ hybridization [FISH]). Yet, identifying the coordinates of the translocation breakpoints in the NSD2 gene using next-generation sequencing (NGS), could uncover the presence of no, early, and late disruption subgroups with different median overall survival (OS). Professional illustration by Somersault18:24.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/141/13/10.1182_blood.2022018007/2/blood_bld-2022-018007-c-gr1.jpeg?Expires=1720281059&Signature=zrXO63P6YN2qCZnlIZGvrJ6jiz2RFQ~fGh0sruJxd8h63ejxLEXrPHf98tjUqB2kP3LoVw5Ivw27lKThsH7Ybt0wN~bNC-yCabPzicvXjIksYh3tEJbqEYNsCNKWCCM~9YxXPHukb5AXtfHdAbxVkXqeNlpxZoh~1g5pqGv6J4L0z31LcSdYKtXDqkPIuAwzznxEpkHBo-IafpdMGpuIPsejRYm688i4FYPoF6O6ixZIgXX8CDn2O-harVcq9Rhc27L-SO9JsS9Na~G7LDKbjlf3o7zRhMrUPc1yF12oIPUc-s631MBtig5l~JFomkaRdpUz8UIo4t46H-edGae3kQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The presence of multiple t(4;14) myelomas is illustrated in this schematic figure. Tumor cells from patients with t(4;14) may look similar under the microscope during morphologic and cytogenetic assessments (using fluorescence in situ hybridization [FISH]). Yet, identifying the coordinates of the translocation breakpoints in the NSD2 gene using next-generation sequencing (NGS), could uncover the presence of no, early, and late disruption subgroups with different median overall survival (OS). Professional illustration by Somersault18:24.
