Tregs expressing oIL-2Rβ significantly expand in vivo in the presence of oIL-2 and ameliorate aGVHD at a Tcon to Treg ratio of 5:1 in a mouse MHC mismatch model of HSCT. In contrast, unexpanded oIL-2Rβ Tregs (in the absence of oIL-2) and WT Tregs in the presence of oIL-2 do not expand and have virtually no effect on aGVHD. This figure was created with BioRender.com.

Tregs expressing oIL-2Rβ significantly expand in vivo in the presence of oIL-2 and ameliorate aGVHD at a Tcon to Treg ratio of 5:1 in a mouse MHC mismatch model of HSCT. In contrast, unexpanded oIL-2Rβ Tregs (in the absence of oIL-2) and WT Tregs in the presence of oIL-2 do not expand and have virtually no effect on aGVHD. This figure was created with BioRender.com.

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