Figure 3.
Certain structural features differentiate PA, NA, and NB antibodies. Number of total amino acid residues (A), basic residues (B), and Tyr residues (C) in HCDR3 of 7 PA, 47 NA, and 40 NB clones. (D) HCDR3 sequences of PA clones. RX1-2R/KX1-2R/H (RKH) and YYYYY (Y5) motifs are highlighted in red. (E) Prevalence of clones possessing the RKH and Y5 motifs among PA, NA, and NB antibodies. P values were calculated by the unpaired 2-tailed Student t-test (A-C) and by Fisher exact test (E). Error bars indicate mean ± SD. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001.

Certain structural features differentiate PA, NA, and NB antibodies. Number of total amino acid residues (A), basic residues (B), and Tyr residues (C) in HCDR3 of 7 PA, 47 NA, and 40 NB clones. (D) HCDR3 sequences of PA clones. RX1-2R/KX1-2R/H (RKH) and YYYYY (Y5) motifs are highlighted in red. (E) Prevalence of clones possessing the RKH and Y5 motifs among PA, NA, and NB antibodies. P values were calculated by the unpaired 2-tailed Student t-test (A-C) and by Fisher exact test (E). Error bars indicate mean ± SD. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001.

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