Considerations regarding the long-term management of atypical HUS patients. (A) Proposed algorithm for the long-term management of aHUS. (B) Special considerations regarding (1) pregnancy-associated atypical HUS and pregnancy in women with a history of atypical HUS, (2) infectious complications of C5 blockade in atypical HUS patients, and (3) surgery in atypical HUS patients. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; siRNA, silencing RNA.