CONSORT diagram of publication and patient workflow for inclusion in the final cohort. Includes 7 patients with variants recategorized as LB/B (included in supplemental Table 1). DC, discontinuation; LB/B, likely benign or benign; LP/P, likely pathogenic or pathogenic; NA, not available; NP, not performed; STEC-HUS, Shiga toxin-producing Escherichia coli hemolytic uremic syndrome; VUS, variant of uncertain significance.