BM and PB MRD NGF metrics, concordance, and test performance. Analyses were performed on matched BM/PB pairs (n = 70) postInd3. The NGF metrices: (A) acquired nucleated cell number, (B) LOD, and (C) LOQ are given for the BM and PB samples. (D) Concordance is shown of BM and PB NFG MRD results after treatment, evaluated at 2 cutoffs (1 × 10E-05 and 1 × 10E-06). (E) PB MRD test performance is calculated. Cases with discordance due to nonassessable BM MRD (n = 3) were not considered. BM, bone marrow; FN, false negative; FP, false positive; LOD, limit of detection; LOQ, limit of quantification; MRD, measurable residual disease; NGF, next-generation flow cytometry; NPV, negative predictive value; PB, peripheral blood; postInd3, after 3 cycles of induction therapy; PPV, positive predictive value; TN, true negative; TP, true positive.