Combination of OTSSP167 with drugs used in remission induction. (A) Analysis of OTSSP167 combined with Dex in KOPTK-1 cells. (B) Analysis of OTSSP167 and ASNase combination in KOPTK-1 cells. The color bar representing the degree of synergism vs antagonism is the same as in (A). (C) Analysis of OTSSP167 combined with vincristine VCN in KOPTK-1 cells. (D) Analysis of OTSSP167 combined with a mixture of ASNase + DEX + VCN in KOPT-K1 cells. The color bar represents the degree of synergism vs antagonism as in (C). (E) Combination of OTSSP167 and etoposide in MOLT-3 cells. (F) Cytotoxicity of OTSSP167 to normal bone marrow cells compared with T-ALL PDX cells treated for 24 hours. ∗∗P < .01, ∗∗∗∗P < .0001 two-tailed Student t test was used in (F).