Combined analysis of perinatal outcomes in our case series and those reported in 2 previously published case series (Chan et al 2018, Zhang et al 2021). Forest plots with 95% confidence intervals comparing patients who received optimal IUTs (OT, ≥2 IUTs) and those with suboptimal IUTs (SOT, 0-1 IUT). Denominators for each analysis reflect the number of patients for whom the data were available. (A) At the time of birth, hydrops resolved in 17/18 (94.4%) OT and 3/9 (33.3%) SOT fetuses (OR 3.25 [0.90, 5.60]; P = .01). (B) The number of births at ≥34 weeks was 21/27 (77.8%) in OT vs 3/19 (15.8%) in SOT patients (OR 2.92 [1.36, 4.47]; P = .003). (C) OT patients were significantly more likely than SOT patients to have reassuring APGAR scores (≥7) at 5 minutes (OT: 16/18 (88.2%) vs SOT: 5/12 (41.6%) (OR 2.44 [0.59, 4.30]; P = .01). (D) OT patients were significantly more likely than SOT patients to have average or greater neurodevelopment (OT: 17/18 (94.4%) vs SOT 5/13 (38.5%) (OR 2.74 [0.76, 4.71]; P = .01).