Vineland-3 percentile score and correlation with GA at the first IUT. (A) Composite Vineland percentile score vs GA at first IUT (Pearson r = −0.72, P = .02). (B) Communication subdomain Vineland percentile (Pearson r = −0.82, P = .004). In each graph, the filled circles represent patients in group 1, and the triangle represents a group 1 patient with a nondeletion variant (Hb H Adana). The empty circle represents a patient who was born spontaneously at 28 weeks and diagnosed after birth (this patient was not included in the statistical analysis to evaluate the impact of IUTs on neurodevelopment). The superior dotted line corresponds to 1 standard deviation below the mean (sixteenth percentile); which signifies the risks of developmental delay. The inferior dotted line corresponds to 2 standard deviations below the mean (2.5^th percentile); which signifies the risks for intellectual disability and is not seen in any patient in the transfused cohort.