(A) Age-related risk of developing MN in male and female carriers of DDX41 risk alleles. Cumulative incidence was estimated by kin-cohort analysis using 525 first-degree relatives. (B) Kaplan-Meier survival plots of MDS patients with DDX41-WT or DDX41-mutations stratified by IPSS-R. See Figures 3F and 6C in the article by Makishima et al that begins on page 534.