RROL is transcribed from MIR17HG lncRNA and mediates the assembly of the MYC-WDR82 protein complex and promotes its occupancy in the promoter region of the ACC1 gene, leading to the expression of ACC1 and to the proliferation of MM cells. Therapeutic antisense oligonucleotides (ASOs) against RROL expression dismantle the RROL-MYC-WDR82-ACC1 complex, resulting in an antiproliferation effect for MM cells. Created with BioRender.com.