Link between the presence of anti-ADAMTS13 autoantibodies against different domains and clinical outcomes in Japanese patients. (A-C) Patients with anti-M autoantibodies showed more severe thrombocytopenia and higher levels of LDH and serum creatinine than patients without anti-M autoantibodies. (D) Patients with anti-T6T8 autoantibodies had higher levels of serum creatinine than patients without anti-T6T8 autoantibodies. (E) Patients with anti–CUB1-2 autoantibodies had higher levels of LDH than those without anti–CUB1-2 autoantibodies.