Cumulative TTP-related mortality and anti-ADAMTS13 autoantibody immunoprofiles in the Japanese iTTP cohort. The left panel represents the 1-year cumulative TTP-related mortality in patients with immunoprofile 1 compared with patients with other immunoprofiles. The right panel shows the 1-year cumulative TTP-related mortality in patients with anti-ADAMTS13 autoantibodies against the 6 ADAMTS13 domains (M, DT, CS, T2-T5, T6-T8, and CUB1-2), compared with patients with anti-ADAMTS13 autoantibodies against the 5 or less ADAMTS13 domains.