Fine-mapping of anti-ADAMTS13 autoantibodies in the Japanese iTTP cohort. Fine-mapping of anti-ADAMTS13 autoantibodies was done using ELISA by studying the binding of the anti-ADAMTS13 autoantibodies to M, DT, CS, T2-T5, T6-T8, and CUB1-2 domains. The percentage of patient samples containing anti-M, anti-DT, anti-CS, anti-T2-T5, anti-T6-T8, or anti–CUB1-2 autoantibodies among the 159 patients are depicted. C, cysteine-rich; CUB, complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1; D, disintegrin-like; M, metalloprotease; S, spacer; T, thrombospondin type 1 repeat.