Histopathologic (H&E stain) assessment of canine livers at postmortem in AAV-treated dogs (A-D) and an untreated control (E-H). Foci of hepatocyte nodular hyperplasia (A-B and E-F) characterized by nonencapsulated areas of hepatocyte proliferation (A,E: magnification ×50) with mildly thickened liver cell plates (B,F: magnification ×400). Also observed were ill-defined regions of liver parenchyma pallor due to hepatocyte cytoplasmic clearing (C: magnification ×15; G: magnification ×25), characteristic of canine vacuolar hepatopathy (D,H: magnification ×400).