Consequences of the mutations affecting epigenetic regulators and the mTORC1 signaling pathway in FL. (A) Mutations in epigenetic regulators affect respective histone modifications with a convergence on specific downstream functional effects; (B) RRAGC mutations have an impact on the mTORC1 nutrient signaling pathway and are able to enhance B-cell activation even with a reduction in nutrient levels. MHC, major histocompatibility complex.