Possibilities for the future development of CAR T-cell therapy. Depicted are some of the novel new-generation CAR T constructs, including third-generation CARs incorporating 2 different costimulatory domains; fourth-generation CARs (also named “armored” CARs) incorporating transducible genes codifying for cytokines, antibodies, or receptors (among others); and novel target (non-BCMA) and dual targeting strategies, including tandem CAR and dual CAR.