Changes in cell populations between MGUS and MM for the UAMS, UoH, Zavidij et al, and the combined data set. (A) Cell subsets were divided by degree of log fold change (2.5, 5, 10); ∗P < .1, ∗∗P < .05; asterisks are marked black for each separate data set and red for the combined data set. (B) Heatmap showing expression of 25 cell subsets at the MGUS, SMM, and NDMM stage. HSC, hematopoietic stem cell.