Models of the cell of origin of lineage-switched relapse in infant KMT2A-r leukemia. Tirtakusuma et al. identified 3 different scenarios: (1) relapsed AML cells lack BCR rearrangement; (2) both ALL and AML cells present BCR rearrangements but they are different; and (3) ALL and AML cells share the same BCR rearrangement.

Models of the cell of origin of lineage-switched relapse in infant KMT2A-r leukemia. Tirtakusuma et al. identified 3 different scenarios: (1) relapsed AML cells lack BCR rearrangement; (2) both ALL and AML cells present BCR rearrangements but they are different; and (3) ALL and AML cells share the same BCR rearrangement.

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