![STAT1-dependent MHCIIhi HSCs are less responsive to diverse stress stimuli. High levels of MHCII define a novel HSC subset dependent on STAT1. This subset is less responsive to stress-induced (5-FU or polyinosinic:polycytidylic acid [p:IC]) proliferation and apoptosis. In mutant CALR mice, MHCIIhi HSCs have a low capacity to expand and differentiate into the megakaryocytic lineage. Professional illustration by Somersault18:24.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/140/14/10.1182_blood.2022016850/2/blood_bld-2022-016850-c-gr1.jpeg?Expires=1724858627&Signature=xTIqCFa~pBKvHHhJzjm57~AfcKK6h-iv9ArpU6VSRXITXIFdj3FLmZ9c8lFInaLgz5Gz5cIYM8f0i8gK6ZyvmmuDCo1m0L1jClf2raWboYrkg6KMJ6Yt-dtHiB30vn5M3OV35O5N1NDOs13L726NLC5kAaHqkwZD1Qi0mnr~q5GulS4S1ciRrY7qnJ0U6xgEUK3S-oG0sWo~mzzt6UfGgcQygjwaqoPvm6G~caKMbXB1S96mxozQ1ySlezjoWPnQMZWQuG53mm7Y6lrVVtI9ZFuYHPTEEvknYdet64JisEVue5gLrIjfj5fN1X84B1c6w7Kv~RlqRQ2rCk1rhOdSsQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
STAT1-dependent MHCIIhi HSCs are less responsive to diverse stress stimuli. High levels of MHCII define a novel HSC subset dependent on STAT1. This subset is less responsive to stress-induced (5-FU or polyinosinic:polycytidylic acid [p:IC]) proliferation and apoptosis. In mutant CALR mice, MHCIIhi HSCs have a low capacity to expand and differentiate into the megakaryocytic lineage. Professional illustration by Somersault18:24.
