The early venous thrombotic events are shown, with polymorphonuclear neutrophils (PMNs) as likely sources of IL-1β. This stimulates the endothelial Gab2 pathway, which, via MALT1 and CARAMA3 (CARM3), activates NF-κB and Rho signaling, with tissue factor (TF) and von Willebrand factor (VWF) release, as well as P-selectin (P-sel) and VCAM-1 expression. These factors act to amplify the thromboinflammatory process. NET, neutrophil extracellular trap; PKC, protein kinase C; PLC, phospholipase C; RBC, red blood cell. Professional illustration by Somersault18:24.