Effects of rondoraptivon pegol on VWF antigen, FVIII activity, and aPTT. Rondoraptivon pegol increases circulating von Willebrand factor mass (%) and coagulation factor FVIII activity (%), with a reciprocal normalization of activated partial thromboplastin time (s) (aPTT actin factor specific). Medians are indicated by solid lines and stars. The horizontal dashed lines indicate the lower normal range for VWF and FVIII and the upper normal range for the aPTT. Note logarithmic scale of y axis for VWF and FVIII layers.