Effects of rondoraptivon pegol on platelet counts. Rondoraptivon pegol increases platelet counts (×10E9/L) in patients with VWD type 2B. Rondoraptivon pegol was given as 3 mg on days 0, 4, and 7, followed by up-titration to 6 to 9 mg at weekly intervals. The highest dose was only given to patients with thrombocytopenia at baseline (open symbols). The horizontal dashed line indicates the lower normal range. The solid line with the stars indicates the median with standard deviation error bars.